Homer-1a immediate early gene expression correlates with better cognitive performance in aging
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چکیده
منابع مشابه
Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression.
Three Homer genes regulate the activity of metabotropic glutamate receptors mGluR1a and mGluR5 and their coupling to releasable intracellular Ca2+ pools and ion channels. Only the Homer 1 gene evolved bimodal expression of constitutive (Homer 1b and c) and immediate early gene (IEG) products (Homer 1a and Ania 3). The IEG forms compete functionally with the constitutive Homer proteins. The comp...
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The transcription of the immediate-early genes Arc and Homer 1a (H1a) is dynamically regulated in response to synaptic activity; their protein products function at the postsynaptic sites of excitatory synapses. Previous studies demonstrate a role for Arc in the maintenance of long-term potentiation and in memory consolidation processes and indicate a role for H1a in modifying glutamatergic sign...
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ژورنال
عنوان ژورنال: AGE
سال: 2012
ISSN: 0161-9152,1574-4647
DOI: 10.1007/s11357-012-9479-6